Bramanti P, Ricci R M, Mailland F, Di Perri R
Institut für Neurologische und Neurochirurgische Wissenschaften, Universität von Messina, Italien.
Arzneimittelforschung. 1992 Nov;42(11A):1403-6.
The aim of this study was to assess the effect induced by the dopamine agonist dihydroergocristine (DHEC, CAS 17479-19-5), whose memory-improving activity is well-known, on sleep pattern and cognitive function, and the possible relationship between them. Ten elderly volunteers were included in the study. Selected subjects had to be neither demented nor depressed, according to neuropsychodiagnostic criteria (SCAG < 30, Hachinski dementia score < or = 15, Hachinski ischemic score < 6, HRSD < or = 22). All subjects underwent a nightly polysomnographic evaluation during placebo, after single and long-term once-daily 6 mg DHEC administration. Cognitive function and attention were also assessed by the Randt memory test and WAIS digit-symbol subtest. DHEC caused a marked and significant increase in the acquisition subitem, and memory improvement was documented during DHEC treatment. A significant direct relationship between the effect of DHEC on REM sleep and memory test was also evidenced. Our results confirmed the role of REM sleep in the restoration of cognitive function.
本研究的目的是评估多巴胺激动剂二氢麦角隐亭（DHEC，化学物质登记号17479 - 19 - 5）对睡眠模式和认知功能的影响以及它们之间可能的关系，该激动剂改善记忆的活性是众所周知的。10名老年志愿者被纳入本研究。根据神经心理诊断标准（SCAG＜30，哈金斯基痴呆评分≤15，哈金斯基缺血评分＜6，HRSD≤22），入选的受试者既不能患有痴呆症也不能患有抑郁症。所有受试者在服用安慰剂期间、单次及长期每日一次服用6毫克DHEC后均接受了夜间多导睡眠图评估。认知功能和注意力也通过兰特记忆测试和韦氏成人智力量表数字符号分测验进行评估。DHEC使习得子项显著增加，并且在DHEC治疗期间记录到记忆改善。还证实了DHEC对快速眼动睡眠的影响与记忆测试之间存在显著的直接关系。我们的结果证实了快速眼动睡眠在认知功能恢复中的作用。
