Greiner P O, Charles P, Bonnet M, Angignard D, Dupont J M, Herold M, Borzeix M G
Institut de Recherche SIR International, Montrouge, France.
Neurobiol Aging. 1992 Jul-Aug;13(4):527-9. doi: 10.1016/0197-4580(92)90082-9.
After evaluation of activity in an open field, norepinephrine (NE), serotonin (5HT), 5-hydroxyindolacetic acid (5HIAA), homovanillic acid (HVA), and choline acetyltransferase (CAT) were investigated in cortex of 26-month-old rats poisoned with methylazoxymethanol (MAM) as compared to control rats of the same age. NE and 5HT concentrations showed a marked increase, but levels were normal when expressed as total content, just as in MAM-exposed young adults. Concentrations of 5HIAA were also increased but to a lesser extent than 5 HT. Aged MAM rats did not show any modification of spontaneous activity although hyperactivity is characteristic of young adults exposed to MAM. Together with this behavioral observation, a significant decrease in total HVA content was measured. Because HVA levels seem correlated with activity in MAM-exposed rats, we speculate that the behavioral abnormality recovers in old age. Total CAT activity was also reduced. These results indicate that the neurochemical pattern of young adult MAM-poisoned rats is conserved in aged rats except for some changes in the dopaminergic and cholinergic systems.
在对旷场活动进行评估后，研究了26月龄经甲基氧化偶氮甲醇（MAM）中毒的大鼠与同龄对照大鼠皮质中的去甲肾上腺素（NE）、血清素（5-羟色胺，5HT）、5-羟吲哚乙酸（5HIAA）、高香草酸（HVA）和胆碱乙酰转移酶（CAT）。NE和5HT浓度显著升高，但以总含量表示时水平正常，这与暴露于MAM的年轻成年大鼠情况相同。5HIAA浓度也升高，但程度低于5HT。老年MAM大鼠未表现出自发活动的任何改变，尽管多动是暴露于MAM的年轻成年大鼠的特征。结合这一行为观察结果，测得总HVA含量显著降低。由于HVA水平似乎与暴露于MAM的大鼠的活动相关，我们推测行为异常在老年时恢复。总CAT活性也降低。这些结果表明，除了多巴胺能和胆碱能系统的一些变化外，年轻成年MAM中毒大鼠的神经化学模式在老年大鼠中得以保留。
