Cuéllar A, Frenk S
Unidad de Investigación en Salud Infantil, Instituto Nacional de Pediatría, México, D.F.
Bol Med Hosp Infant Mex. 1992 Dec;49(12):813-22.
In the last 3 decades, the discovery of importance of trace elements in structure and functions of many enzymes, provided a tremendous impetus for research on the physiopathology, metabolism, clinical pharmacology and toxicology of these micronutrients in human beings, specially, in children. This paper presents recent information on various pathological inherited and acquired conditions, with abnormal nutritional status in children, due either to deficiency or excess of some oligo-elements. The general aspects of abnormal metabolism, physiopathology, and some specific clinical features, are described.
在过去三十年中，微量元素在许多酶的结构和功能中的重要性被发现，这为研究这些微量营养素在人类尤其是儿童中的生理病理学、代谢、临床药理学和毒理学提供了巨大动力。本文介绍了有关儿童因某些微量元素缺乏或过量而导致营养状况异常的各种遗传性和后天性病理状况的最新信息。描述了代谢异常、生理病理学的一般方面以及一些特定的临床特征。
