一项关于奥美拉唑与华法林在抗凝治疗患者中相互作用的研究。
A study of the interaction of omeprazole and warfarin in anticoagulated patients.
作者信息
Unge P, Svedberg L E, Nordgren A, Blom H, Andersson T, Lagerström P O, Idström J P
机构信息
Department of Medicine, Sandviken Hospital, Sweden.
出版信息
Br J Clin Pharmacol. 1992 Dec;34(6):509-12. doi: 10.1111/j.1365-2125.1992.tb05656.x.
Abstract
- Thirty-five patients on continuous therapy with warfarin were given omeprazole 20 mg once daily and placebo each for 3 weeks according to a two-centre randomised double-blind cross-over design. 2. Blood samples were obtained once weekly during the run-in and follow-up periods as well as during the first 2 weeks of each treatment period, and twice during the last week of each treatment period. Plasma concentrations of R- and S-warfarin were measured by h.p.l.c. and the anticoagulant effect was assessed using the Trombotest. 3. Twenty-eight patients were evaluated. The mean plasma concentration of R-warfarin was increased by 9.5% during omeprazole treatment compared with placebo, while that of S-warfarin, the more active isomer, was unaffected. The coagulation time was not significantly changed (106 s during omeprazole and 98 s during placebo). Corresponding TT-values (Trombotest) were 8.8 and 9.9 (NS).
摘要
- 根据两中心随机双盲交叉设计，35例接受华法林持续治疗的患者，每天服用一次20毫克奥美拉唑和安慰剂，各服用3周。2. 在导入期和随访期以及每个治疗期的前2周每周采集一次血样，在每个治疗期的最后一周采集两次血样。通过高效液相色谱法测定R-和S-华法林的血浆浓度，并使用凝血试验评估抗凝效果。3. 对28例患者进行了评估。与安慰剂相比，奥美拉唑治疗期间R-华法林的平均血浆浓度升高了9.5%，而活性更强的异构体S-华法林则未受影响。凝血时间无显著变化（奥美拉唑治疗期间为106秒，安慰剂治疗期间为98秒）。相应的凝血试验值（凝血试验）分别为8.8和9.9（无显著性差异）。
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