ALLFREY V, MIRSKY A E
J Gen Physiol. 1952 Jul;35(6):841-6. doi: 10.1085/jgp.35.6.841.
A study of the incorporation of glycine-N(15) by chicken red cells in vitro has shown that: 1. There is no detectable nitrogen turnover in the histone or desoxyribonucleic acid of erythrocytes or reticulocytes. 2. Hemoglobin synthesis in the nucleated reticulocyte proceeds at 2 to 3 times the rate observed in the mature erythrocyte. 3. The uptake of glycine-N(15) by heme is 9 to 14 times the corresponding uptake into hemoglobin, and 12 to 20 times the calculated uptake into globin. 4. Maturation of the red cell results in a decline in the rate of synthesis of both heme and globin, but the deceleration is much more marked in globin. synthesis. 5. No significant differences could be detected in the low N(15) incorporations of nuclear and cytoplasmic hemoglobins.
一项关于鸡红细胞在体外掺入甘氨酸 - N(15) 的研究表明：1. 红细胞或网织红细胞的组蛋白或脱氧核糖核酸中未检测到氮周转。2. 有核网织红细胞中的血红蛋白合成速度是成熟红细胞中观察到速度的2至3倍。3. 血红素对甘氨酸 - N(15) 的摄取量是血红蛋白相应摄取量的9至14倍，是珠蛋白计算摄取量的12至20倍。4. 红细胞成熟导致血红素和珠蛋白的合成速度均下降，但珠蛋白合成的减速更为明显。5. 在核血红蛋白和细胞质血红蛋白的低N(15)掺入中未检测到显著差异。
