Wandl U B, Niederle N
Innere Klinik und Poliklinik (Tumorforschung), Universitätsklinikum Essen, Germany.
Infection. 1992;20 Suppl 2:S107-10. doi: 10.1007/BF01705028.
This paper summarizes different theoretical and clinical approaches contributing to the concept of dose intensification. According to this concept, the amount of antineoplastic drug delivered per time predominantly determines the clinical outcome in patients with neoplastic disease. With the availability of recombinant haemopoietic growth factors haematotoxic side effects might be reduced, making this concept more feasible for clinical use. However, more prospective randomized studies, in which dose-intensity is the only treatment variable, are needed to prove that dose intensification will lead to higher survival rates.
本文总结了促成剂量强化概念的不同理论和临床方法。根据这一概念，每次给予的抗肿瘤药物量在很大程度上决定了肿瘤疾病患者的临床结局。随着重组造血生长因子的出现，血液毒性副作用可能会减少，这使得该概念在临床应用中更具可行性。然而，需要更多将剂量强度作为唯一治疗变量的前瞻性随机研究，以证明剂量强化会导致更高的生存率。
