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[新型隐球菌格特变种引起的隐球菌病。扎伊尔金沙萨一例与获得性免疫缺陷综合征(艾滋病)相关的病例]

[Cryptococcosis caused by Cryptococcus neoformans var. Gattii. A case associated with acquired immunodeficiency syndrome (AIDS) in Kinshasa, Zaire].

作者信息

Muyembe Tamfum J J, Mupapa Kibadi D, Nganda L, Ngwala-Bikindu D, Kuezina T, Kela-We I, Vandepitte J

机构信息

Département de Microbiologie, Université de Kinshasa, Zaïre.

出版信息

Med Trop (Mars). 1992 Oct-Dec;52(4):435-8.

PMID:1494313
Abstract

Since the introduction of AIDS, the biovar neoformans of Cryptococcus neoformans has replaced the biovar gattii as the predominant agent of cryptococcal meningitis in Kinshasa and in other tropical areas. That this is not an absolute rule is demonstrated by the present case of a HIV-positive patient, observed at the Kinshasa University Hospital, with cryptococcal meningitis due to the biovar gattii. Only four cases of this association have been published before. The authors conclude that both biovars are capable of infecting HIV-positive patients but that the apparent decline of the biovar gattii is related to the rarity of its natural reservoir in the urban environment, where the AIDS epidemic is concentrated.

摘要

自艾滋病出现以来,新型隐球菌的新生变种已取代加蒂变种,成为金沙萨和其他热带地区隐球菌性脑膜炎的主要病原体。金沙萨大学医院观察到的一名艾滋病毒阳性患者患加蒂变种所致隐球菌性脑膜炎的当前病例表明,这并非绝对规律。此前仅发表过4例这种关联的病例。作者得出结论,两种变种都能够感染艾滋病毒阳性患者,但加蒂变种明显减少与城市环境中其自然宿主稀少有关,而艾滋病流行集中在城市环境。

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