Strumilo S A, Vinogradov V V
Vopr Pitan. 1978 May-Jun(3):58-60.
The activity of glucose-6-phosphate dehydrogenase (EC 1.1.1.44), transketolase (EC 1.1.1.44), transketolase (EC 1.1.1.49), 6-phosphogluconate dehydrogenase (EC 2.2.1.1.) and also the thiaminediphosphate (TDP) content were investigated on the 8th day after adrenalectomy. With compensated sodium dysbalance the removal of suprarenals is shown not to change the activity of dehydrogenases, but it does lower the transketolase activity and the TDP level. A seven-fold administration to adrenalectomized animals of nicotinic acid, thiamine or a simple injection of nicotinamide normalize the transketolase activity through raising the TDP level. The fact of the reduced transketolase activity in the kidneys in hypocorticotism being due to deficiency of the co-enzyme is also proved by the presence of the TDP-effect in vitro.
在肾上腺切除术后第8天，对葡萄糖-6-磷酸脱氢酶（EC 1.1.1.44）、转酮醇酶（EC 1.1.1.44）、转酮醇酶（EC 1.1.1.49）、6-磷酸葡萄糖酸脱氢酶（EC 2.2.1.1）的活性以及硫胺二磷酸（TDP）含量进行了研究。在钠平衡得到代偿的情况下，切除肾上腺未显示出改变脱氢酶的活性，但确实降低了转酮醇酶的活性和TDP水平。对肾上腺切除的动物给予7倍剂量的烟酸、硫胺素或单纯注射烟酰胺，可通过提高TDP水平使转酮醇酶活性恢复正常。体外存在TDP效应也证明了肾上腺皮质功能减退时肾脏中转酮醇酶活性降低是由于辅酶缺乏这一事实。
