Steyn P S, Thiel P G
Prikl Biokhim Mikrobiol. 1992 Nov-Dec;28(6):894-8.
Strains of the Fusarium moniliforme fungi, widely distributed contaminants of maize are shown to be highly toxic and carcinogenic and cause various animal and human diseases. The effect of temperature and incubation period on the production of fumonisins by F. moniliforme have been studied. The overall maximum yield of fumonisins was 17.5 g/kg maize. A high-performance liquid chromatographic method for the quantitative determination of fumonisins is proposed. The structural analysis of their tetramethylethers was performed by the mass-spectrometry method. It has been established that fumonisins are causative factors in the toxicity of horse leukoencephalomalacia. The possible role of fumonisins in the etiology of oesophageal cancer is discussed.
串珠镰刀菌菌株是广泛分布于玉米中的污染物，已证明其具有高毒性和致癌性，并会引发各种动物和人类疾病。研究了温度和培养时间对串珠镰刀菌产生伏马毒素的影响。伏马毒素的总体最大产量为每千克玉米17.5克。提出了一种用于定量测定伏马毒素的高效液相色谱法。通过质谱法对其四甲基醚进行了结构分析。已确定伏马毒素是马脑白质软化症毒性的致病因素。讨论了伏马毒素在食管癌病因学中的可能作用。
