Ribar S, Mesarić M
Zavod za kemiju i biokemiju, Sveuciliste u Zagrebu, Medicinski fakultet.
Lijec Vjesn. 1998 Mar-Apr;120(3-4):85-91.
Fumonisins are toxic metabolites of the fungus Fusarium moniliforme and several other Fusaria that commonly contaminate corn. Only recently discovered in 1988, these mycotoxins appear to be causative agents of several toxicoses in animals that result from ingestion of moldy corn and corn-based feeds. These include equine leukoencephalomalacia, porcine pulmonary oedema, nephrotoxicity, hepatotoxicity, hepatocarcinogenicity in laboratory animals. There is also evidence that suggests that F. moniliforme and fumonisins may also be responsible for oesophageal cancer in humans in certain areas of the world where moldy corn is frequently consumed. Fumonisins are structurally similar to sphingosine, and may exert their biological activity to block enzymes sphinganine- and sphingosine-N-acyl transferase involved in sphingolipid biosynthesis.
伏马菌素是真菌串珠镰刀菌及其他几种镰刀菌产生的有毒代谢产物，这些真菌通常会污染玉米。直到1988年才被发现，这些霉菌毒素似乎是动物摄入发霉玉米和玉米基饲料后引发多种中毒症的致病因子。这些中毒症包括马脑白质软化症、猪肺水肿、肾毒性、肝毒性、实验动物的肝癌致癌性。也有证据表明，在世界上某些经常食用发霉玉米的地区，串珠镰刀菌和伏马菌素可能也是人类食管癌的病因。伏马菌素在结构上与鞘氨醇相似，可能通过发挥其生物活性来阻断参与鞘脂生物合成的鞘氨醇和鞘氨醇 -N- 酰基转移酶。
