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[不同剂量率照射对C57Bl/6小鼠生存、死亡动力学及关键系统反应的影响特征]

[Characteristics of the effect of irradiation at different dose rates on survival, death kinetics and response of critical systems of the C57Bl/6 mice].

作者信息

Tolstykh E I, Korytnyĭ V S

出版信息

Radiobiologiia. 1992 Nov-Dec;32(6):788-94.

PMID:1494645
Abstract

A comparison was made of the biological effect on mice of irradiation at different dose rates (70, 5.5 and 1.5 cGy/min) with equally effective, with respect to lethality, doses, or with physically equal doses within the range from 1/4 of LD50/30 to LD99-95/30. Equally effective, with respect to lethality, doses caused similar changes in the intestinal epithelium and in the haemopoietic system. The death rate kinetics was identical with doses of LD80-95/30 within the dose-rate range under study. The equally effective doses caused injuries, different in degrees, to critical systems, including CFUs.

摘要

对小鼠在不同剂量率(70、5.5和1.5厘戈瑞/分钟)下进行照射的生物学效应进行了比较,这些剂量率在致死率方面具有同等效力,或者在从LD50/30的1/4到LD99 - 95/30范围内具有物理等量的剂量。在致死率方面同等效力的剂量,会在肠上皮和造血系统中引起相似的变化。在所研究的剂量率范围内,LD80 - 95/30剂量的死亡率动力学是相同的。同等效力的剂量会对包括集落形成单位(CFUs)在内的关键系统造成程度不同的损伤。

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