Afanas'ev G G, Zagurski S, Burachevska I, Shumel' I
Radiobiologiia. 1992 Nov-Dec;32(6):835-43.
Growth kinetics of LY-S and LY-R cells (radiosensitive and radioresistant sublines of murine lymphoma L5178Y) has been investigated after beta-irradiation at cumulative doses of 1.5 to 20 cGy and dose rates of 0.8-10 mGy/h. It has been found that after 48 h culture in a complete medium the number of cells differed 5 times, whereas after X- and gamma-irradiation, Do values differed 1.62 times. Using the growth rate as the end point in evaluating the combined effect of beta-irradiation (10 cGy) and subsequent X-irradiation with lethal doses, we observed an increased relative cell number, in comparison to that after X-irradiation alone (an "adaptive response", using this criterion), in LY-S cells irradiated with a dose of 2 Gy. In contrast, when reproductive death of LY-S and LY-R cells the end-point analyzed, the lethal effect of consecutive beta- and X-irradiation in LY-S cells was higher than that expected for X-radiation alone (the synergistic effect).
在累积剂量为1.5至20 cGy、剂量率为0.8 - 10 mGy/h的β射线照射后，研究了LY - S和LY - R细胞（小鼠淋巴瘤L5178Y的放射敏感和放射抗性亚系）的生长动力学。发现在完全培养基中培养48小时后，细胞数量相差5倍，而在X射线和γ射线照射后，Do值相差1.62倍。以生长速率作为评估β射线照射（10 cGy）与后续致死剂量X射线联合作用的终点，我们观察到，与单独X射线照射后相比（使用此标准的“适应性反应”），在接受2 Gy剂量照射的LY - S细胞中，相对细胞数量增加。相反，当以LY - S和LY - R细胞的生殖死亡作为分析终点时，连续β射线和X射线照射对LY - S细胞的致死效应高于单独X射线照射预期的效应（协同效应）。
