Crouzet J, Berrissoul F, Beraneck L, Juan L H
Service de Rhumatologie et du Service de Pneumologie, Hôpital Gilles de Corbeil, Corbeil-Essonnes.
Rev Rhum Mal Osteoartic. 1992 Oct;59(9):577-80.
The case of a patient who developed sarcoidosis with chronic joint symptoms at the age of four and still has active disease twenty years later despite three years of corticosteroid therapy is reported. During the course of the disease, specific histologic features of sarcoidosis were evidenced twice in synovial specimens, twice in skin biopsy specimens, and once in bronchial tissue. Deformations and joint lesions developed in the hands and feet. The combination of arthritis, skin lesions, and uveitis occurs both in juvenile-onset sarcoidosis and in chronic juvenile joint diseases, raising significant diagnostic problems which can be solved by histologic studies of synovial or skin biopsy specimens.
报告了一例患者，该患者四岁时患结节病并伴有慢性关节症状，尽管接受了三年的皮质类固醇治疗，但二十年后疾病仍处于活动期。在疾病过程中，结节病的特定组织学特征在滑膜标本中出现两次，在皮肤活检标本中出现两次，在支气管组织中出现一次。手部和足部出现畸形和关节病变。关节炎、皮肤病变和葡萄膜炎的组合在青少年起病的结节病和慢性青少年关节疾病中均有发生，这引发了重大的诊断问题，可通过滑膜或皮肤活检标本的组织学研究来解决。
