Billaud E M, Ropers J, Fortineau N, Kreft-Jais C, Babany G
Service de Pharmacologie, hôpital Broussais, Paris.
Therapie. 1992 Jul-Aug;47(4):335-42.
Cyclosporine A is a potent immunosuppressive agent, widely used in organ transplantation, in bone marrow transplantation and in the treatment of some autoimmune diseases. Changes of its absorption, a metabolism mainly processed by the liver and a concentration-related nephrotoxicity lead to the need of a careful drug monitoring, allowing to obtain blood levels that must be low and nevertheless sufficiently efficient. Cyclosporin A may additionally yield some numerous drug interactions. Those with potentially serious issue must be mandatory avoided and distinguished from those less severe that only have to be followed up. The strategy differs according to the nature of the interaction (i.e. pharmacokinetic/pharmacodynamic): the posology will have either to be adjusted or the risk/benefit ratio will have to be taken into account to decide any change in the dosage regimen.
环孢素A是一种强效免疫抑制剂，广泛应用于器官移植、骨髓移植及某些自身免疫性疾病的治疗。其吸收的变化、主要在肝脏进行的代谢以及与浓度相关的肾毒性，使得需要进行仔细的药物监测，以获得低水平但仍足够有效的血药浓度。环孢素A还可能产生许多药物相互作用。必须强制避免那些具有潜在严重问题的相互作用，并将其与那些只需随访的不太严重的相互作用区分开来。根据相互作用的性质（即药代动力学/药效学），策略会有所不同：要么调整剂量，要么必须考虑风险/效益比以决定剂量方案的任何改变。
