老年人大脑中β-淀粉样蛋白前体水平与tau转录本之间的一种新关联。

A novel correlation between the levels of beta-amyloid protein precursor and tau transcripts in the aged human brain.

作者信息

Oyama F, Shimada H, Oyama R, Titani K, Ihara Y

机构信息

Division of Biomedical Polymer Science, School of Medicine, Fujita Health University, Aichi, Japan.

出版信息

J Neurochem. 1992 Sep;59(3):1117-25. doi: 10.1111/j.1471-4159.1992.tb08354.x.

DOI:10.1111/j.1471-4159.1992.tb08354.x

PMID:1494902

Abstract

beta-Amyloid protein precursor (APP) and tau are implicated in the pathogenesis of Alzheimer's disease. We quantified the levels of APP and tau transcripts in the three cortical regions of 38 aged human brains obtained from consecutive autopsied patients. The level of APP mRNA was directly proportional to that of tau mRNA to a remarkable extent, suggesting coordinate expression of the APP and tau genes, whereas much weaker correlations were noted among mRNAs encoding other neuronal proteins. From the previous data on the differential expression of APP and tau mRNAs, the levels of APP-751 and -695 mRNAs were calculated and found to be proportional to those of four-repeat and three-repeat tau mRNAs, respectively, whereas that of APP-770 mRNA was rather constant. These results suggest that the mRNA concentrations of APP isoforms are linked to those of tau isoforms in the aged human brain.

摘要

β-淀粉样蛋白前体（APP）和tau蛋白与阿尔茨海默病的发病机制有关。我们对38例连续尸检患者的老年人大脑三个皮质区域中APP和tau转录本的水平进行了定量。APP mRNA的水平在很大程度上与tau mRNA的水平成正比，表明APP和tau基因的协同表达，而编码其他神经元蛋白的mRNA之间的相关性则弱得多。根据先前关于APP和tau mRNA差异表达的数据，计算出APP-751和-695 mRNA的水平，发现它们分别与四重复和三重复tau mRNA的水平成正比，而APP-770 mRNA的水平相当恒定。这些结果表明，在老年人脑中APP异构体的mRNA浓度与tau异构体的mRNA浓度相关。