Fisher S R, Langford J, Molter D W, Seigler H F
Department of Surgery, Duke University Medical Center, Durham, NC 27710.
Laryngoscope. 1992 Aug;102(8):850-4. doi: 10.1288/00005537-199208000-00002.
Historically, Breslow classified thin melanomas as invasive lesions less than 0.76 mm in depth with rare instances of recurrence and mortality. From 1970 to 1990, 87 patients with thin head and neck melanoma were treated at Duke Medical Center. A computer-aided retrospective analysis was performed. Recurrence occurred in 30% of these patients; however, of the 66 patients seen at this institution prior to recurrence, only 8% recurred. Recurrence significantly shortened survival. Compared to an overall 84% 5-year survival, there was less than a 50% 5-year survival after recurrence. For thin melanomas, thickness did not affect survival. There was no difference in survival between thin melanomas and those ranging from 0.76 to 1.5 mm. A multivariate analysis was performed. The data suggest that thin melanomas of the head and neck may recur at a higher rate than previously reported and in addition, that they can be lethal.
从历史上看，布雷斯洛将薄型黑色素瘤归类为深度小于0.76毫米的浸润性病变，复发和死亡率罕见。1970年至1990年期间，杜克医学中心治疗了87例头颈部薄型黑色素瘤患者。进行了计算机辅助回顾性分析。这些患者中有30%出现复发；然而，在该机构复发前就诊的66例患者中，只有8%复发。复发显著缩短了生存期。与总体84%的5年生存率相比，复发后的5年生存率不到50%。对于薄型黑色素瘤，厚度并不影响生存期。薄型黑色素瘤与厚度在0.76至1.5毫米之间的黑色素瘤在生存期上没有差异。进行了多变量分析。数据表明，头颈部薄型黑色素瘤的复发率可能比之前报道的更高，此外，它们可能是致命的。
