Esposito V, Federico P, Lo Iudice G, Rispoli C, Sabatino P, D'Alessandro B
Cattedra di Scienza delle Costituzioni, Università degli Studi di Napoli, Federico II.
Minerva Endocrinol. 1992 Jan-Mar;17(1):21-9.
To investigate the sex hormone status of women with polycystic ovary syndrome (PCO) and to relate this to serum levels of glucose, insulin, lipids and lipoproteins, 90 women with PCO (30 obese: BMI greater than 30 kg/m2; 30 overweight: BMI greater than 25- less than 30 kg/m2; 30 non obese: BMI less than 25 kg/m2) and 60 normal ovulatory women (20 obese; 20 overweight; 20 non obese) were studied. The women with PCO had significantly increased LH, FSH and androgen levels and significantly decreased SHBG levels compared to the normal women. Obese women with PCO had higher concentrations of fasting glucose, fasting insulin, incremental glucose area, incremental insulin area and lipid than overweight and non obese women with PCO and overweight and non obese control subjects, but were similar in obese normal women. There were decreases in high-density lipoproteins levels in both the obese groups (obese PCO and obese control women). Lipid and lipoprotein concentrations did not differ in the obese, overweight and non obese PCO women compared to the normal groups while HDL cholesterol were decreased in obese PCO and obese control women. The correlations between hormone, glucose, insulin, lipid and lipoprotein levels were different among the six groups. Non obese PCO women had: inverse correlations between free testosterone and incremental glucose area (r = -0.5128, P = 0.03); positive correlations between SHBG and alpha-lipoproteins (r = 0.9159, P = 0.001). Non obese normal women had: positive correlations between fasting insulin and total testosterone (r = 0.5272, P = 0.043) and between SHBG and beta-lipoproteins (r = 0.7445, P = 0.014) and LDL cholesterol (r = 0.7360, P = 0.010).(ABSTRACT TRUNCATED AT 250 WORDS)
为研究多囊卵巢综合征（PCO）女性的性激素状态，并将其与血清葡萄糖、胰岛素、脂质及脂蛋白水平相关联，对90例PCO女性（30例肥胖：BMI大于30kg/m²；30例超重：BMI大于25至小于30kg/m²；30例非肥胖：BMI小于25kg/m²）和60例正常排卵女性（20例肥胖；20例超重；20例非肥胖）进行了研究。与正常女性相比，PCO女性的促黄体生成素（LH）、促卵泡生成素（FSH）和雄激素水平显著升高，性激素结合球蛋白（SHBG）水平显著降低。肥胖的PCO女性空腹血糖、空腹胰岛素、葡萄糖增量面积、胰岛素增量面积和脂质浓度高于超重及非肥胖的PCO女性以及超重和非肥胖的对照受试者，但与肥胖的正常女性相似。两组肥胖人群（肥胖的PCO女性和肥胖的对照女性）的高密度脂蛋白水平均降低。与正常组相比，肥胖、超重和非肥胖的PCO女性的脂质和脂蛋白浓度无差异，而肥胖的PCO女性和肥胖的对照女性的高密度脂蛋白胆固醇降低。六组人群中激素、葡萄糖、胰岛素、脂质和脂蛋白水平之间的相关性各不相同。非肥胖的PCO女性：游离睾酮与葡萄糖增量面积呈负相关（r = -0.5128，P = 0.03）；SHBG与α-脂蛋白呈正相关（r = 0.9159，P = 0.001）。非肥胖的正常女性：空腹胰岛素与总睾酮呈正相关（r = 0.5272，P = 0.043），SHBG与β-脂蛋白呈正相关（r = 0.7445，P = 0.014），与低密度脂蛋白胆固醇呈正相关（r = 0.7360，P = 0.010）。（摘要截断于250字）
