MORRIONE T G
J Exp Med. 1952 Aug;96(2):107-14. doi: 10.1084/jem.96.2.107.
Collagen fibers have been formed in vitro by the action of heparm on solutions of collagen. Heparin was found to be effective in inducing collagen fiber formation when present in concentrations as low as 1-80,000. It is postulated that mast cells, by virtue of the heparin which they produce, may play a role in the formation of collagen.
通过肝素对胶原蛋白溶液的作用,已在体外形成了胶原纤维。发现当肝素浓度低至1-80,000时,它在诱导胶原纤维形成方面是有效的。据推测,肥大细胞凭借其产生的肝素,可能在胶原蛋白的形成中起作用。