妊娠期急性尿酸肾病
Acute uric acid nephropathy in pregnancy.
作者信息
Alexopoulos E, Tampakoudis P, Bili H, Mantalenakis S
机构信息
First Department of Obstetrics and Gynecology, Aristotelian University of Thessaloniki, Hippokration General Hospital, Greece.
出版信息
Obstet Gynecol. 1992 Sep;80(3 Pt 2):488-9.
BACKGROUND
Although uric acid clearance increases during gestation, uric acid nephropathy is a rare cause of acute renal failure in the pregnant woman.
CASE
A 38-year-old woman experienced acute renal failure due to acute uric acid nephropathy at 30 weeks' gestation. The diagnosis was based on extreme hyperuricemia and an elevated uric acid-creatinine ratio. Treatment with forced diuresis, urine alkalinization, and mannitol infusion resulted in a prompt and complete recovery of renal function. The woman ultimately gave birth to a healthy child.
CONCLUSION
Acute uric acid nephropathy during pregnancy responds to conventional medical therapy.
背景
尽管孕期尿酸清除率会增加，但尿酸肾病是孕妇急性肾衰竭的罕见病因。
病例
一名38岁女性在妊娠30周时因急性尿酸肾病发生急性肾衰竭。诊断依据是极度高尿酸血症和尿酸肌酐比值升高。通过强制利尿、尿液碱化及输注甘露醇治疗，肾功能迅速且完全恢复。该女性最终产下一名健康婴儿。
结论
孕期急性尿酸肾病对传统药物治疗有反应。
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