Sowers J R
Endocrinology and Hypertension Division, Wayne State University School of Medicine, Detroit, MI 48201.
Postgrad Med. 1992 Aug;92(2):265-8. doi: 10.1080/00325481.1992.11701430.
Hypertension is a constellation of abnormalities, including metabolic disorders. The current approach to treatment of hypertension should not be dictated solely by measures to lower blood pressure. It must also take into consideration the effect of antihypertensive drug treatment on the development of atherosclerosis and many other important factors. Evidence from rabbit models and cell cultures indicates that calcium channel blockers are antiatherogenic through a variety of mechanisms. In addition to preserving endothelial function, these agents inhibit the following: Platelet aggregation Migration of monocytes and smooth-muscle cells into the intima Incorporation of low-density lipoprotein cholesterol into these cells Matrix formation Calcium overload in atherosclerotic lesions However, additional studies are needed to delineate the antiatherogenic effects of these and other antihypertensive agents.
高血压是一系列异常情况，包括代谢紊乱。当前高血压的治疗方法不应仅由降低血压的措施来决定。它还必须考虑抗高血压药物治疗对动脉粥样硬化发展的影响以及许多其他重要因素。来自兔模型和细胞培养的证据表明，钙通道阻滞剂通过多种机制具有抗动脉粥样硬化作用。除了维持内皮功能外，这些药物还可抑制以下方面：血小板聚集；单核细胞和平滑肌细胞向内膜的迁移；低密度脂蛋白胆固醇进入这些细胞；基质形成；动脉粥样硬化病变中的钙超载。然而，需要进一步的研究来阐明这些及其他抗高血压药物的抗动脉粥样硬化作用。
