用睾酮进行预处理可增强青春期延迟男孩的生长激素分泌。
Priming with testosterone enhances stimulated growth hormone secretion in boys with delayed puberty.
作者信息
Müller G, Keller A, Reich A, Hoepffner W, Kratzsch J, Buckler J M, Kiess W, Keller E
机构信息
Children's Hospital, University of Leipzig, Germany.
出版信息
J Pediatr Endocrinol Metab. 2004 Jan;17(1):77-83. doi: 10.1515/jpem.2004.17.1.77.
BACKGROUND AND OBJECTIVE
Tests for growth hormone (GH) deficiency are not always helpful in the differential diagnosis of physiological delay of growth and puberty and GH deficiency.
PATIENTS AND METHODS
To enhance diagnostic specificity, we used a single dose testosterone priming before repeating the arginine stimulation test in 26 boys with short stature and only early signs of puberty who failed to show an adequate response of serum GH in the first test.
RESULTS
77% (20/26 patients) increased their serum GH peak to more than 10 ng/ml, whereas six patients were still below this concentration.
CONCLUSION
We propose that testosterone priming is a useful tool to distinguish between physiological delay of growth and puberty and GH deficiency and should be included in the diagnostic procedure.
背景与目的
生长激素（GH）缺乏症的检测对于生长和青春期生理性延迟与GH缺乏症的鉴别诊断并非总是有帮助。
患者与方法
为提高诊断特异性，我们对26名身材矮小且仅有青春期早期体征、首次试验中血清GH反应不足的男孩，在重复精氨酸刺激试验前使用单剂量睾酮激发。
结果
77%（20/26例患者）血清GH峰值升高至超过10 ng/ml，而6例患者仍低于此浓度。
结论
我们认为睾酮激发是区分生长和青春期生理性延迟与GH缺乏症的有用工具，应纳入诊断程序。
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