生长激素刺激试验：检测还是不检测？这是其中一个问题。
Growth Hormone Stimulation Testing: To Test or Not to Test? That Is One of the Questions.
机构信息
Division of Pediatric Endocrine and Diabetes, Mount Sinai Kravis Children's Hospital, New York, NY, United States.
出版信息
Front Endocrinol (Lausanne). 2022 Jun 9;13:902364. doi: 10.3389/fendo.2022.902364. eCollection 2022.
Abstract
The evaluation of children with short stature includes monitoring over a prolonged period to establish a growth pattern as well as the exclusion of chronic medical conditions that affect growth. After a period of monitoring, evaluation, and screening, growth hormone stimulation testing is considered when the diagnosis of growth hormone deficiency (GHD) is entertained. Though flawed, growth hormone stimulation tests remain part of the comprehensive evaluation of growth and are essential for the diagnosis of growth hormone (GH) deficiency. Variables including testing length, growth hormone assay and diagnostic cut off affect results. Beyond the intrinsic issues of testing, results of GH stimulation testing can be influenced by patient characteristics. Various factors including age, gender, puberty, nutritional status and body weight modulate the secretion of GH.
摘要
儿童身材矮小的评估包括长时间监测以建立生长模式，以及排除影响生长的慢性疾病。在进行一段时间的监测、评估和筛查后，如果考虑生长激素缺乏症（GHD）的诊断，则会进行生长激素刺激测试。尽管存在缺陷，但生长激素刺激测试仍是生长综合评估的一部分，对于生长激素（GH）缺乏症的诊断至关重要。测试时间、生长激素检测和诊断截止值等变量会影响结果。除了测试本身的内在问题外，患者特征也会影响 GH 刺激测试的结果。各种因素，包括年龄、性别、青春期、营养状况和体重，都会调节 GH 的分泌。
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