孔细胞仅通过穿孔素/颗粒酶途径杀伤P815肿瘤细胞。 - Suppr

Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway.

作者信息

Vermijlen David, Luo Dianzhong, Froelich Christopher J, Medema Jan P, Kummer Jean A, Willems Erik, Braet Filip, Wisse Eddie

机构信息

Laboratory for Cell Biology and Histology, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium.

出版信息

Comp Hepatol. 2004 Jan 14;3 Suppl 1(Suppl 1):S58. doi: 10.1186/1476-5926-2-S1-S58.

DOI:10.1186/1476-5926-2-S1-S58

PMID:14960210

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2410270/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64af/2410270/538b83d97833/1476-5926-3-S1-S58-1.jpg

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本文引用的文献

Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway.

J Leukoc Biol. 2002 Oct;72(4):668-76.

Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.

Immunity. 2002 Mar;16(3):417-28. doi: 10.1016/s1074-7613(02)00286-8.

Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.

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Regulation and antimetastatic functions of liver-associated natural killer cells.

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Serglycin secreted by leukocytes is efficiently eliminated from the circulation by sinusoidal scavenger endothelial cells in the liver.

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Perforin and Fas/Fas ligand-mediated cytotoxicity in acute and chronic woodchuck viral hepatitis.

Clin Exp Immunol. 1999 Oct;118(1):63-70. doi: 10.1046/j.1365-2249.1999.01010.x.

Involvement of LFA-1 in hepatic NK cell (pit cell)-mediated cytolysis and apoptosis of colon carcinoma cells.

J Hepatol. 1999 Jul;31(1):110-6. doi: 10.1016/s0168-8278(99)80170-6.

Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis.

J Exp Med. 1999 Jan 4;189(1):131-44. doi: 10.1084/jem.189.1.131.

Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.

J Biol Chem. 1998 Dec 18;273(51):34278-83. doi: 10.1074/jbc.273.51.34278.

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Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway.

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