孔细胞仅通过穿孔素/颗粒酶途径杀伤P815肿瘤细胞。 - Suppr

Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway.

作者信息

Vermijlen David, Luo Dianzhong, Froelich Christopher J, Medema Jan P, Kummer Jean A, Willems Erik, Braet Filip, Wisse Eddie

机构信息

Laboratory for Cell Biology and Histology, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium.

出版信息

Comp Hepatol. 2004 Jan 14;3 Suppl 1(Suppl 1):S58. doi: 10.1186/1476-5926-2-S1-S58.

DOI:10.1186/1476-5926-2-S1-S58

PMID:14960210

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2410270/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64af/2410270/538b83d97833/1476-5926-3-S1-S58-1.jpg

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Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway.孔细胞仅通过穿孔素/颗粒酶途径杀伤P815肿瘤细胞。

Comp Hepatol. 2004 Jan 14;3 Suppl 1(Suppl 1):S58. doi: 10.1186/1476-5926-2-S1-S58.

Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway.肝脏自然杀伤细胞仅通过穿孔素/颗粒酶途径杀伤脾脏/血液中对自然杀伤细胞有抗性的肿瘤细胞。

J Leukoc Biol. 2002 Oct;72(4):668-76.

Pit cells (Hepatic natural killer cells) of the rat induce apoptosis in colon carcinoma cells by the perforin/granzyme pathway.大鼠的肝窦自然杀伤细胞通过穿孔素/颗粒酶途径诱导结肠癌细胞凋亡。

Hepatology. 1999 Jan;29(1):51-6. doi: 10.1002/hep.510290143.

A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death.除穿孔素和肿瘤坏死因子α外，颗粒酶B在同种异体反应性细胞毒性T淋巴细胞诱导的小鼠胰腺β细胞死亡中起关键作用。

Transplantation. 2006 Jan 27;81(2):146-54. doi: 10.1097/01.tp.0000191939.68451.d9.

Rat CD4+CD8+ macrophages kill tumor cells through an NKG2D- and granzyme/perforin-dependent mechanism.大鼠CD4+CD8+巨噬细胞通过NKG2D和颗粒酶/穿孔素依赖性机制杀伤肿瘤细胞。

J Immunol. 2008 Mar 1;180(5):2999-3006. doi: 10.4049/jimmunol.180.5.2999.

Human T regulatory cells can use the perforin pathway to cause autologous target cell death.人类调节性T细胞可利用穿孔素途径导致自体靶细胞死亡。

Immunity. 2004 Oct;21(4):589-601. doi: 10.1016/j.immuni.2004.09.002.

Early pregnancy decidual lymphocytes beside perforin use Fas ligand (FasL) mediated cytotoxicity.早期妊娠蜕膜淋巴细胞除了使用穿孔素外，还利用Fas配体（FasL）介导细胞毒性。

J Reprod Immunol. 2007 Apr;73(2):108-117. doi: 10.1016/j.jri.2006.07.001. Epub 2006 Sep 6.

Bcl-2 protects against Fas-based but not perforin-based T cell-mediated cytolysis.Bcl-2可抵御基于Fas的而非基于穿孔素的T细胞介导的细胞溶解作用。

Int Immunol. 1996 Jul;8(7):991-1000. doi: 10.1093/intimm/8.7.991.

Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly decreases the expression of perforin, granzyme A and granulysin in human NK-92CI cell line.二氯二苯醚菊酯（DDVP）显著降低人NK-92CI细胞系中穿孔素、颗粒酶A和颗粒溶素的表达。

Toxicology. 2005 Sep 15;213(1-2):107-16. doi: 10.1016/j.tox.2005.05.018.

Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway.细胞毒性T淋巴细胞的连续杀伤作用：T细胞受体通过非颗粒途径触发脱颗粒、溶细胞颗粒的重新填充以及溶细胞蛋白的分泌。

Eur J Immunol. 1995 Apr;25(4):1071-9. doi: 10.1002/eji.1830250432.

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The Provocative Roles of Platelets in Liver Disease and Cancer.血小板在肝脏疾病和癌症中的激发作用。

Front Oncol. 2021 Jul 21;11:643815. doi: 10.3389/fonc.2021.643815. eCollection 2021.

本文引用的文献

J Leukoc Biol. 2002 Oct;72(4):668-76.

Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation.细胞毒性细胞颗粒介导的凋亡：穿孔素将颗粒酶B-丝甘蛋白聚糖复合物递送至靶细胞，而不形成质膜孔。

Immunity. 2002 Mar;16(3):417-28. doi: 10.1016/s1074-7613(02)00286-8.

Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.甘露糖 6-磷酸/胰岛素样生长因子 II 受体是细胞毒性 T 细胞诱导凋亡过程中颗粒酶 B 的死亡受体。

Cell. 2000 Oct 27;103(3):491-500. doi: 10.1016/s0092-8674(00)00140-9.

Regulation and antimetastatic functions of liver-associated natural killer cells.肝脏相关自然杀伤细胞的调节及抗转移功能

Immunol Rev. 2000 Apr;174:63-76. doi: 10.1034/j.1600-0528.2002.00014h.x.

Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo.细胞毒性淋巴细胞颗粒成分在体外和体内的促凋亡功能。

Curr Opin Immunol. 2000 Jun;12(3):323-9. doi: 10.1016/s0952-7915(00)00094-7.

Serglycin secreted by leukocytes is efficiently eliminated from the circulation by sinusoidal scavenger endothelial cells in the liver.白细胞分泌的丝甘蛋白聚糖可被肝脏中肝血窦的清道夫内皮细胞有效地从循环系统中清除。

J Leukoc Biol. 2000 Feb;67(2):183-8. doi: 10.1002/jlb.67.2.183.

Perforin and Fas/Fas ligand-mediated cytotoxicity in acute and chronic woodchuck viral hepatitis.穿孔素和Fas/Fas配体介导的细胞毒性在急慢性土拨鼠病毒性肝炎中的作用

Clin Exp Immunol. 1999 Oct;118(1):63-70. doi: 10.1046/j.1365-2249.1999.01010.x.

Involvement of LFA-1 in hepatic NK cell (pit cell)-mediated cytolysis and apoptosis of colon carcinoma cells.淋巴细胞功能相关抗原-1参与肝自然杀伤细胞（pit细胞）介导的结肠癌细胞细胞溶解及凋亡过程。

J Hepatol. 1999 Jul;31(1):110-6. doi: 10.1016/s0168-8278(99)80170-6.

Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis.颗粒酶B诱导的细胞凋亡的线粒体依赖性和非依赖性调节

J Exp Med. 1999 Jan 4;189(1):131-44. doi: 10.1084/jem.189.1.131.

Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.颗粒酶B模拟顶端半胱天冬酶。对刽子手半胱天冬酶-3和-7反式激活统一途径的描述。

J Biol Chem. 1998 Dec 18;273(51):34278-83. doi: 10.1074/jbc.273.51.34278.

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Pit cells exclusively kill P815 tumor cells by the perforin/granzyme pathway.

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