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激素的使用与滥用:作为青春源泉的激素与体育界兴奋剂之间的区别是什么?

Hormone use and abuse: what is the difference between hormones as fountain of youth and doping in sports?

作者信息

van der Lely A J

机构信息

Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.

出版信息

J Endocrinol Invest. 2003 Sep;26(9):932-6. doi: 10.1007/BF03345246.

Abstract

GH can induce changes in body composition that are considered to be advantageous to aging subjects especially. However, there are no results indicating that the use of GH during aging should be advocated, because of the lack of any proven efficacy for whatever parameter. Also, data indicate that calorie restriction can extend life spans by altering the rate of decline in reserve capacity as well as by reducing the cumulative exposure to GH. Moreover, animal data suggest that lower GH actions are positively correlated with longevity. The abuse of GH by sportsmen is based on the belief that it has potent anabolic effects, while it is difficult to detect the abuse. Again, this supposed efficacy cannot be supported by any scientific data.

摘要

生长激素(GH)可引起身体成分的变化,这些变化尤其被认为对老年受试者有利。然而,没有结果表明在衰老过程中使用生长激素应得到提倡,因为无论对于何种参数,都缺乏任何已证实的疗效。此外,数据表明,热量限制可通过改变储备能力的下降速率以及减少对生长激素的累积暴露来延长寿命。而且,动物数据表明,较低的生长激素作用与长寿呈正相关。运动员滥用生长激素是基于这样一种信念,即它具有强大的合成代谢作用,而这种滥用行为很难被检测到。同样,这种所谓的疗效也没有任何科学数据支持。

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