Stoupel Elijah, Kalediene Ramune, Petrauskiene Jadviga, Israelovich Peter, Abramson Evgeny, Sulkes Jaqueline
Division of Cardiology and Epidemiology Unit, Rabin Medical Center, Sackler School of Medicine, Petach Tikva, Israel.
J Basic Clin Physiol Pharmacol. 2003;14(3):225-33. doi: 10.1515/jbcpp.2003.14.3.225.
The natural history of terminal oncologic disease is death from cardiopulmonary arrest. The goal of this study was to determine whether the temporal distribution of death among oncology patients is related to levels of environmental physical activity-solar, geomagnetic, and cosmic rays and high energy space proton flux, as previously shown for other situations like accidents, suicide, and the occurrence of acute myocardial infarction.
Deaths of oncology patients, n = 102604, in 168 consecutive months were compared with-monthly indices of solar, geomagnetic, cosmic rays activity (sunspot number, solar flux, Ap, Cp, Am), and indices of magnetic and cosmic rays activity according to neutron monitor data). In addition, oncology patients monthly death numbers were compared with numbers of deaths from ischemic heart disease (IHD), stroke, sudden cardiac death (SCD), accidents, road accidents, non cardiovascular death (total deaths - [IHD + stroke]). The National Data of the Republic of Lithuania was used, excluding SCD and myocardial infarction in Kaunas--the second largest city in Lithuania Monica study register was used for SCD at age 25-64, and all data of AMI. Pearson correlation coefficients and their probabilities were obtained between the numbers of oncology patient monthly deaths and (1) cosmo-physical indices and (2) the number of deaths from other causes and the occurrence of AMI.
The number of oncology patient deaths was inversely correlated with solar and geomagnetic activity indices and positively correlated with cosmic rays activity. The number of oncology patient deaths was correlated with monthly number of deaths from non-cardiovascular courses, stroke, suicide, at trend level with SCD, but not with deaths from IHD, accidents, road accidents. Oncology patient deaths showed a significant correlation with the number of AMI.
The monthly death number of oncology patients is significantly related with environmental physical activity and shows similarity with deaths distribution by time of some other groups of death--stroke, SCD, suicide, and occurrence of AMI. The inverse correlation with solar and geomagnetic activity and positive links with cosmic rays activity level are remarkable.
晚期肿瘤疾病的自然转归是死于心肺骤停。本研究的目的是确定肿瘤患者死亡的时间分布是否与环境体力活动水平（太阳、地磁和宇宙射线以及高能空间质子通量）相关，正如之前在事故、自杀和急性心肌梗死发生等其他情况中所显示的那样。
将102604例肿瘤患者在连续168个月中的死亡情况与太阳、地磁、宇宙射线活动的月度指数（太阳黑子数、太阳通量、Ap、Cp、Am）以及根据中子监测数据得出的磁和宇宙射线活动指数进行比较。此外，将肿瘤患者的月度死亡人数与缺血性心脏病（IHD）、中风、心源性猝死（SCD）、事故、道路事故、非心血管死亡（总死亡人数 - [IHD + 中风]）的死亡人数进行比较。使用了立陶宛共和国的国家数据，排除了立陶宛第二大城市考纳斯的心源性猝死和心肌梗死——25 - 64岁心源性猝死使用莫妮卡研究登记数据，以及急性心肌梗死的所有数据。获得了肿瘤患者月度死亡人数与（1）宇宙物理指数以及（2）其他原因的死亡人数和急性心肌梗死发生情况之间的皮尔逊相关系数及其概率。
肿瘤患者死亡人数与太阳和地磁活动指数呈负相关，与宇宙射线活动呈正相关。肿瘤患者死亡人数与非心血管疾病、中风、自杀的月度死亡人数相关，在心源性猝死方面呈趋势性相关，但与缺血性心脏病、事故、道路事故的死亡人数无关。肿瘤患者死亡与急性心肌梗死的发生有显著相关性。
肿瘤患者的月度死亡人数与环境体力活动显著相关，并且与其他一些死亡群体（中风、心源性猝死、自杀以及急性心肌梗死的发生）的死亡时间分布相似。与太阳和地磁活动的负相关以及与宇宙射线活动水平的正相关关系显著。
