Howell Eric, Johnson Sandra Marchese
Brody School of Medicine at East Carolina University, Greenville, North Carolina, USA.
J Drugs Dermatol. 2004 Jan-Feb;3(1):83-5.
Thalidomide is increasingly being used for the treatment of a variety of dermatologic conditions. Some of the risks associated with thalidomide use, however, are still being uncovered. Increased incidence of venous thrombosis following thalidomide use has recently been reported in the treatment of diseases with disease-related thrombotic risks, such as malignancy and lupus with antiphospholipid antibody syndrome. We report a case of venous thrombosis resulting from thalidomide use in a patient with cicatricial pemphigoid, illustrating the potential concern for increased thrombosis following thalidomide use in the dermatology setting.
沙利度胺越来越多地被用于治疗多种皮肤病。然而，与使用沙利度胺相关的一些风险仍在不断被发现。最近有报道称，在治疗具有疾病相关血栓形成风险的疾病（如恶性肿瘤和伴有抗磷脂抗体综合征的狼疮）时，使用沙利度胺后静脉血栓形成的发生率增加。我们报告了1例瘢痕性类天疱疮患者使用沙利度胺后发生静脉血栓形成的病例，说明了在皮肤科环境中使用沙利度胺后血栓形成增加的潜在问题。
