Kurhaliuk N M
Franko Lviv National University, Ukraine.
Ukr Biokhim Zh (1999). 2002 Jul-Aug;74(4):85-90.
Effects Crebs Cycle of exogenous intermediates sodium succinate (50 mg/kg) and sodium alpha-ketoglutarate (200 mg/kg) on processes of mitochondrial ADP-stimulated respiration (using as substrates of oxidation 0.35 mM succinate, 1 mM alpha-ketoglutarate), production of nitric oxide under NO2-, NO3-, as well as carbamide, putrescyne content and processes of lipid peroxidation in the rats liver under acute hypoxia (7% O2 in N2, 30 min) have been studied. It was shown, that the exogenous sodium alpha-ketoglutarate increases nitric oxide content, aminotransferase activation, inhibition of succinatedehydrogenase simultaneously more than exogenous sodium succinate. It correlates with decreasing of processes lipid peroxidation in liver.
研究了外源性中间产物琥珀酸钠（50毫克/千克）和α-酮戊二酸钠（200毫克/千克）对线粒体ADP刺激呼吸过程（使用0.35毫摩尔琥珀酸盐、1毫摩尔α-酮戊二酸作为氧化底物）、急性缺氧（氮气中7%氧气，30分钟）大鼠肝脏中NO2-、NO3-以及尿素、腐胺含量下一氧化氮生成和脂质过氧化过程的影响。结果表明，外源性α-酮戊二酸钠比外源性琥珀酸钠更能同时增加一氧化氮含量、激活转氨酶、抑制琥珀酸脱氢酶。这与肝脏中脂质过氧化过程的减少相关。
