[胆小管胆汁形成过程中的胆汁酸]
[Bile acids in the process of canalicular bile formation].
作者信息
Sinel'nik T B, Sinel'nik O D, Ribal'chenko V K
机构信息
Institute of Physiology of Biology Faculty of Taras Shevchenko, National Kiev University.
出版信息
Fiziol Zh (1994). 2003;49(6):80-93.
This review summarizes the current knowledge of the role of bile acid in the canalicular bile secretion: its membrane transport in hepatocyte; molecular mechanisms and pathways of its regulatory effects on membrane transporters; the role of its hydrophobicity in membrane transporter regulation; hepatocyte necrosis and apoptosis at cholestasis induced by hydrophobic bile acids; the possible mechanisms of protective effects of ursodeoxycholic acid in cholestatic impairment of the liver.
本综述总结了目前关于胆汁酸在胆小管胆汁分泌中的作用的知识
其在肝细胞中的膜转运；其对膜转运蛋白的调节作用的分子机制和途径；其疏水性在膜转运蛋白调节中的作用；疏水性胆汁酸诱导胆汁淤积时肝细胞的坏死和凋亡；熊去氧胆酸在胆汁淤积性肝损伤中的保护作用的可能机制。
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