You Guofeng
Department of Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers-The State University of New Jersey, Piscataway, NJ 08854, USA.
Curr Drug Metab. 2004 Feb;5(1):55-62. doi: 10.2174/1389200043489207.
Transporters for organic anions and organic cations in kidney, liver, intestine, brain, and placenta play essential roles in drug disposition. The cloning and characterization of these transporters have significantly advanced our understanding of the molecular and cellular mechanisms of the drug disposition process. This review aims at updating the recent knowledge of general properties, structure-function relationships, and regulation mechanisms of the organic anion transporters (OATs) and the organic cation transporters (OCTs). Such information will be essential for the design and development of new drugs to maximize therapeutic efficacy and minimize drug-induced toxicity as well as unwanted drug-drug interactions.
肾脏、肝脏、肠道、大脑和胎盘内的有机阴离子和有机阳离子转运体在药物处置过程中发挥着重要作用。这些转运体的克隆和特性研究极大地推动了我们对药物处置过程分子和细胞机制的理解。本综述旨在更新有关有机阴离子转运体（OATs）和有机阳离子转运体（OCTs）的一般特性、结构-功能关系及调控机制的最新知识。这些信息对于设计和开发新药以最大化治疗效果、最小化药物诱导的毒性以及避免不必要的药物-药物相互作用至关重要。
