2002年新药的合成方法。

Synthetic approaches to the 2002 new drugs.

作者信息

Li Jin, Liu Kevin K-C

机构信息

Pfizer Global Research and Development, Pfizer Inc., Groton CT 06340, USA.

出版信息

Mini Rev Med Chem. 2004 Feb;4(2):207-33. doi: 10.2174/1389557043487457.

DOI:10.2174/1389557043487457

PMID:14965293

Abstract

New drugs are introduced to the market every year and each individual drug represents a privileged structure for its biological target. In addition, these new chemical entities (NCEs) not only provide insights into molecular recognition, but also serve as drug-like leads for designing future new drugs. Therefore, it is important to be acquainted with these new structures as well as their syntheses. To these ends, this review covers the syntheses of 28 NCEs marketed in 2002.

摘要

每年都有新药投放市场，每种药物对于其生物靶点而言都代表着一种独特的结构。此外，这些新化学实体（NCEs）不仅能为分子识别提供见解，还可作为设计未来新药的类药先导物。因此，熟悉这些新结构及其合成方法很重要。为此，本综述涵盖了2002年上市的28种新化学实体的合成方法。