Crompton M
Department of Biochemistry and Molecular Biology, University College London, Gower St., London WC1E 6BT, UK.
Aging Cell. 2004 Feb;3(1):3-6. doi: 10.1046/j.1474-9728.2003.00073.x.
When mitochondria are subjected to oxidative stress and relatively high [Ca2+], they undergo a "permeability transition" in which the inner membrane becomes freely permeable to low-molecular-weight solutes. This phenomenon reflects reversible deformation of the adenine nucleotide translocase, the loss of its native gating properties and the stabilization of the deformed state by cyclophilin-D. The permeability transition may be a factor in cell dysfunction associated with aging. This can manifest in a number of ways ranging, in the most severe, from impaired energy transduction and compromised viability to more subtle influences on the propagation of Ca2+ signals. This article critically examines data relevant to this issue.
当线粒体受到氧化应激和相对较高的[Ca2+]作用时，它们会经历一种“通透性转变”，即内膜对低分子量溶质变得自由通透。这种现象反映了腺嘌呤核苷酸转位酶的可逆变形、其天然门控特性的丧失以及亲环蛋白-D对变形状态的稳定作用。通透性转变可能是与衰老相关的细胞功能障碍的一个因素。这可以通过多种方式表现出来，最严重的情况是从能量转导受损和生存能力受损到对Ca2+信号传导的更微妙影响。本文批判性地审视了与该问题相关的数据。
