Gobbi H, Atkinson J B, Kardos T F, Simpson J F, Page D L
Breast Consultation Service, Division of Anatomic Pathology, Vanderbilt University Medical Center, Nashville, TN, USA.
Breast. 1999 Jun;8(3):135-8. doi: 10.1054/brst.1999.0045.
Inflammatory myofibroblastic tumours (IMTs) or inflammatory pseudo-tumours are uncommon lesions of unknown aetiology. The majority of the cases are reported in the lungs of young patients. Extra-pulmonary anatomic locations include the abdomen and pelvis, but rare cases have been described in the breast. We describe an IMT in an 86-year-old female, presenting as a well-circumscribed palpable mass in the left breast. Histologically the remarkable feature was the presence of giant vacuolated cells intermixed with spindle cells and a prominent plasma cell infiltrate immersed in a fibrous hyalinized stroma. Immunohistochemical and electron microscopy studies demonstrated the myofibroblastic nature of the giant vacuolated cells and the spindle cells, and the polyclonal nature of the plasma cells. The morphologic and immunohistochemical findings supported the diagnosis of IMT. The biological behaviour of IMT in this age group is unknown and surgical excision with close mammographic follow-up is considered to be appropriate treatment for this lesion in the breast.
炎性肌成纤维细胞瘤（IMTs）或炎性假瘤是病因不明的罕见病变。大多数病例报道于年轻患者的肺部。肺外解剖部位包括腹部和骨盆，但罕见病例发生于乳腺。我们描述了一名86岁女性的IMT，表现为左乳腺可触及的边界清楚的肿块。组织学上，显著特征是存在与梭形细胞混合的巨大空泡化细胞以及浸润于纤维玻璃样变间质中的显著浆细胞浸润。免疫组织化学和电子显微镜研究证实了巨大空泡化细胞和梭形细胞的肌成纤维细胞性质以及浆细胞的多克隆性质。形态学和免疫组织化学结果支持IMT的诊断。该年龄组IMT的生物学行为尚不清楚，手术切除并密切进行乳房X线摄影随访被认为是乳腺该病变的合适治疗方法。
