Gozzetti Alessandro, Crupi Rosaria, Tozzuoli Daniela
Department of Medicine and Immunological Sciences, University of Siena, Italy.
Hematology. 2004 Feb;9(1):11-5. doi: 10.1080/10245330310001652446.
As a result of the low proliferative index, only 50% of chronic lymphocytic leukemia cases are adequate for cytogenetic analysis. Of these, about half have clonal abnormalities. The application of fluorescence in situ hybridization (FISH) to CLL has substantially enhanced our ability to detect chromosomal aberrations; the incidence of a number of recurring abnormalities has been established, providing new insights into the pathogenesis of this disease with a direct impact on the prognosis.
由于增殖指数较低，仅50%的慢性淋巴细胞白血病病例适合进行细胞遗传学分析。其中，约一半存在克隆性异常。荧光原位杂交（FISH）技术应用于慢性淋巴细胞白血病，极大地提高了我们检测染色体畸变的能力；已确定了一些常见异常的发生率，为该疾病的发病机制提供了新见解，对预后有直接影响。
