嗜酸性粒细胞之谜。
The eosinophil enigma.
作者信息
Williams Timothy J
机构信息
Biomedical Sciences Division, School of Medicine, Imperial College London, London, United Kingdom.
出版信息
J Clin Invest. 2004 Feb;113(4):507-9. doi: 10.1172/JCI21073.
Abstract
Eosinophils accumulate in high numbers in the lungs of asthmatic patients. These cells have the ability to induce tissue damage, a capacity that relates to their traditional role in host defense against parasitic worms. On the other hand, eosinophils produce growth factors associated with tissue repair and remodeling, notably TGF-beta1. The relationship of these activities to lung dysfunction in asthma is highly controversial, but recent observations in humans and in animal models add spice to the debate.
摘要
嗜酸性粒细胞在哮喘患者的肺部大量积聚。这些细胞具有诱导组织损伤的能力，这种能力与其在宿主抵御寄生虫的传统作用有关。另一方面，嗜酸性粒细胞会产生与组织修复和重塑相关的生长因子，尤其是转化生长因子β1。这些活动与哮喘中肺功能障碍的关系极具争议，但最近在人类和动物模型中的观察为这场争论增添了趣味。
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本文引用的文献
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Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics.抗白细胞介素-5治疗可减少轻度特应性哮喘患者支气管上皮下基底膜中细胞外基质蛋白的沉积。
J Clin Invest. 2003 Oct;112(7):1029-36. doi: 10.1172/JCI17974.
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Eosinophils and interleukin-5: the debate continues.嗜酸性粒细胞与白细胞介素-5：争论仍在继续。
Am J Respir Crit Care Med. 2003 Jun 15;167(12):1586-7. doi: 10.1164/rccm.2304001.
4
Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study.人源化抗人白细胞介素-5抗体SCH55700对重度持续性哮喘的疗效：一项初步研究。
Am J Respir Crit Care Med. 2003 Jun 15;167(12):1655-9. doi: 10.1164/rccm.200206-525OC. Epub 2003 Mar 20.
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Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway.嗜酸性粒细胞的作用仍不明确，因为抗白细胞介素-5仅能部分减少哮喘气道中的嗜酸性粒细胞数量。
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