Zhuang Zhao-xia, Lin Zhi-yong, Cao Jin-fang
Department of Periodontology, School of Stomatology, Shandong University, Jinan 250012, China.
Shanghai Kou Qiang Yi Xue. 2003 Oct;12(5):362-5.
To investigate the biocompatibility of chitosan-carboxymethylchitosan as membrane for periodontal guided tissue regeneration (GTR).
Chitosan-carboxymethylchitosan blending membrane was prepared by freeze-drying and tests including cytotoxicity test, inserting the membrane into the rabbits, muscles, were employed to investigate its biocompatibility.
Chitosan-carboxymethylchitosan blending membrane showed no toxicity. In early period after the insertion of the membrane, inflammatory processes with macrophages were observed, but the processes reduced with the membrane degradation.
Chitosan-carboxymethylchitosan blending membrane has desirable biocompatibility.
