Onyemelukwe G C, Jibril H B
Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
Trop Geogr Med. 1992 Jan;44(1-2):37-41.
A prospective study of Nigerian children with sickle cell disease was undertaken to determine serum levels of antithrombin III (AT-III) and compare these with normal controls. Mean serum AT-III was significantly lower in patients than in controls (14.51 +/- 4.84 mg/dl and 17.75 +/- 5.92 mg/dl) respectively. Seven of the 49 sickle cell patients had AT-III levels below 50% of normal values. Mean platelet counts were significantly higher in sicklers than in normal controls. AT-III deficiency may predispose to thrombotic complications in children with sickle cell disease.
对患有镰状细胞病的尼日利亚儿童进行了一项前瞻性研究，以测定抗凝血酶III（AT-III）的血清水平，并将其与正常对照组进行比较。患者的平均血清AT-III水平显著低于对照组，分别为（14.51±4.84mg/dl和17.75±5.92mg/dl）。49例镰状细胞病患者中有7例AT-III水平低于正常值的50%。镰状细胞病患者的平均血小板计数显著高于正常对照组。AT-III缺乏可能使镰状细胞病患儿易发生血栓并发症。
