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红细胞悬液中剪切相关过程的电导测定研究。I. 红细胞聚集体形态对血液电导率的影响。

Conductometric study of shear-dependent processes in red cell suspensions. I. Effect of red blood cell aggregate morphology on blood conductance.

作者信息

Pribush A, Meyerstein D, Meyerstein N

机构信息

Dr. Joseph Kaufmann Hematology Laboratory, Physiology Department, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

出版信息

Biorheology. 2004;41(1):13-28.

PMID:14967887
Abstract

The conductance and capacitance of flowing and quiescent red blood cell (RBC) suspensions were measured at a frequency of 0.2 MHz. The results demonstrate that the time-dependent changes in the conductance recorded during the aggregation process differ in nature for suspensions of short linear rouleaux, branched aggregates and RBC networks. It is shown that the conductance of RBC suspensions measured during the aggregation and disaggregation processes follows the morphological transformations of the RBC aggregates. Thus, this method enables characterization of the morphology of RBC aggregates formed in whole blood and in suspensions with physiological hematocrits both under flow conditions and in stasis. These results in combination with previous ones suggest that this technique can be used for studies of dynamic RBC aggregation and probably for diagnostic use.

摘要

在0.2MHz频率下测量了流动和静态红细胞(RBC)悬液的电导和电容。结果表明,在聚集过程中记录的电导随时间的变化,对于短线性叠连、分支聚集体和RBC网络的悬液而言,其性质有所不同。结果表明,在聚集和解聚过程中测量的RBC悬液的电导遵循RBC聚集体的形态转变。因此,该方法能够表征在流动条件和静态下全血以及具有生理血细胞比容的悬液中形成的RBC聚集体的形态。这些结果与之前的结果相结合表明,该技术可用于动态RBC聚集的研究,并且可能用于诊断用途。

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