Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Ito Y, Tamakoshi A
Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan.
Int J Obes Relat Metab Disord. 2004 Apr;28(4):551-8. doi: 10.1038/sj.ijo.0802603.
To determine whether body size measurements are risk factors for colon cancer death among the Japanese.
A nationwide prospective study, the Japan Collaborative Cohort (JACC) Study from 1988 to 1999. The present analysis included 43 171 men and 58 775 women aged 40-79 y who respond to a questionnaire on current weight and height, weight around 20 y of age, and other lifestyle factors. Body mass index (BMI) at baseline and 20 y of age (B-BMI and 20-BMI, respectively) were calculated.
We identified 127 deaths from colon cancer during the follow-up of 424 698 person-years among men and 122 deaths during the follow-up of 591 787 person-years among women. After adjustments for the lifestyle factors known to modify the risk of colon cancer, weight at baseline showed a significant positive association in women, while no such association was seen in men. There was also a significant trend of increasing risk with the increase in B-BMI among women. Women with B-BMI >/=28 kg/m(2) had a relative risk (RR) of 3.41 (95% confidence interval (CI): 1.44-8.06) compared with those with BMI of 20-<22 kg/m(2). 20-BMI also presented the same trend of increasing risk as B-BMI. Women with 20-BMI of <22 and B-BMI of >26 kg/m(2), that is, excessive BMI gain, had a high RR of 3.41 (95% CI 1.29-9.02) compared with those with 20-BMI of <22 and B-BMI of <22 kg/m(2). There were no corresponding trends of colon cancer risk for B-BMI, 20-BMI, or BMI change among men.
These study data suggest that obesity and excessive weight gain are associated with the risk of colon cancer death in Japanese women but no such relationship was found in Japanese men.
确定身体尺寸测量指标是否为日本人结肠癌死亡的风险因素。
一项全国性前瞻性研究，即1988年至1999年的日本合作队列（JACC）研究。本分析纳入了43171名年龄在40 - 79岁的男性和58775名年龄在40 - 79岁的女性，这些人回复了一份关于当前体重和身高、20岁左右时的体重以及其他生活方式因素的问卷。计算了基线时和20岁时的体重指数（BMI，分别为B - BMI和20 - BMI）。
在男性424698人年的随访期间，我们确定了127例结肠癌死亡病例；在女性591787人年的随访期间，确定了122例结肠癌死亡病例。在对已知会改变结肠癌风险的生活方式因素进行调整后，基线体重在女性中显示出显著的正相关，而在男性中未观察到这种相关性。女性中，随着B - BMI的增加，风险也有显著的上升趋势。与BMI为20 - <22 kg/m²的女性相比，B - BMI≥28 kg/m²的女性相对风险（RR）为3.41（95%置信区间（CI）：1.44 - 8.06）。20 - BMI也呈现出与B - BMI相同的风险上升趋势。20 - BMI<22且B - BMI>26 kg/m²，即BMI过度增加的女性，与20 - BMI<22且B - BMI<22 kg/m²的女性相比，RR高达3.41（95% CI 1.29 - 9.02）。男性中，B - BMI、20 - BMI或BMI变化均未出现相应的结肠癌风险趋势。
这些研究数据表明，肥胖和体重过度增加与日本女性结肠癌死亡风险相关，但在日本男性中未发现这种关系
