非典型二肽类抗精神病药双肽的作用所潜在的神经调节机制
Neuromodulatory mechanism underlying the effect of the atypical dipeptide neuroleptic dilept.
作者信息
Retyunskaya M V, Guzevatykh L S, Bondarenko N A, Gudasheva T A, Ostrovskaya R U, Voronina T A
机构信息
Institute of Pharmacology, Russian Academy of Medical Sciences.
出版信息
Bull Exp Biol Med. 2003 Nov;136(5):467-70. doi: 10.1023/b:bebm.0000017095.86326.ab.
Abstract
We studied the effects of a new dipeptide neuroleptic Dilept (N-caproyl-L-prolyl-L-tyrosine methyl ester) on activity of neurotransmitter systems in the brain. Dilept possessed antidopamine, glutamate modulatory, and cholinomimetic properties. These data indicate that Dilept is of potential efficacy in relieving positive and negative symptoms of schizophrenia.
摘要
我们研究了一种新型二肽抗精神病药物Dilept（N-己酰基-L-脯氨酰-L-酪氨酸甲酯）对大脑神经递质系统活性的影响。Dilept具有抗多巴胺、调节谷氨酸以及拟胆碱特性。这些数据表明，Dilept在缓解精神分裂症的阳性和阴性症状方面具有潜在疗效。
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