Sasada M, Sawada H, Nakamura T, Uchino H
Gan. 1978 Jun;69(3):407-12.
Neocarzinostatin, an antineoplastic agent which is effective against human leukemia, induced unscheduled DNA synthesis in human leukemic leucocytes. This indicated the existence of repair process against at least a part of DNA damage caused by the agent. The extent of unscheduled DNA synthesis increased in parallel with the concentration of Neocarzinostatin up to 5 microgram/ml, followed by a decline at more than 5 microgram/ml. Leucocytes from patients with chronic myelogenous leukemia had higher repair synthesis after Neocarzinostatin treatment compared to those from patients with acute leukemia. The amount of repair synthesis correlated well with the proportion of immature leucocytes among chronic myelogenous leukemia samples, but such correlation was not found among acute leukemia samples.
新制癌菌素是一种对人类白血病有效的抗肿瘤药物，它能诱导人类白血病白细胞进行DNA的非预定合成。这表明存在针对该药物引起的至少部分DNA损伤的修复过程。DNA的非预定合成程度与新制癌菌素浓度平行增加，直至5微克/毫升，超过5微克/毫升后则下降。慢性粒细胞白血病患者的白细胞在新制癌菌素治疗后的修复合成高于急性白血病患者的白细胞。修复合成量与慢性粒细胞白血病样本中未成熟白细胞的比例密切相关，但在急性白血病样本中未发现这种相关性。
