Shima Hiroki
Department of Urology, Hyogo College of Medicine.
Nihon Rinsho. 2004 Feb;62(2):262-74.
Internal sexual organs are differentiated and developed by androgens and regressed by müllerian inhibiting substance(anti-müllerian hormone). The role of 5 alpha-dihydrotestosterone, reduced form of testosterone by 5 alpha-reductase, in terms of development of Wolffian duct is discussed with soluble mesenchymal factor responsible for the epithelial branching morphogenesis of mouse seminal vesicle on the basis of experimental results using organ culture assay of mouse new-born seminal vesicle. An update of müllerian inhibiting substance, a fetal regressor of female internal organs such as uterus, fallopian tubes and upper third vagina, is also discussed.
内生殖器由雄激素分化发育，并由苗勒氏管抑制物质（抗苗勒氏激素）退化。基于新生小鼠精囊的器官培养实验结果，探讨了经5α-还原酶还原形成的5α-双氢睾酮在中肾管发育方面的作用，以及与小鼠精囊上皮分支形态发生相关的可溶性间充质因子。文中还讨论了苗勒氏管抑制物质的最新情况，它是子宫、输卵管和阴道上三分之一等女性内器官的胎儿期退化因子。
