Koike Toshimitsu, Araki Shigeo
Central Clinic.
Nihon Rinsho. 2004 Feb;62(2):397-403.
Precocious puberty has been defined as the development of secondary sex characteristics before 8 years of age in girls. In the past, therapy with progestational agents, such as medroxyprogesterone acetate or cyproterone acetate had been used. The gonadotropine releasing hormone agonist has been used widely. The ethiologies of delayed sexual development are numerous. A series of 191 patients with delayed pubertal development is reported in this study. Gonadal dysgenesis is 39/119(32.8%), physiologic delay is 27/119(22.7%), Rokitansky syndrome is 17/119(14.3%), hyperprolactinemia is 11/119(9.2%). The girls with physiological delay, hyperprolactinemia or poly cystic ovary syndrome, have subsequent normal reproductive potential. In the treatment of abnormal pubertal development, the individual treatment is important.
性早熟被定义为女孩在8岁之前出现第二性征发育。过去曾使用过孕激素类药物进行治疗，如醋酸甲羟孕酮或醋酸环丙孕酮。促性腺激素释放激素激动剂已被广泛应用。性发育延迟的病因众多。本研究报告了一系列191例青春期发育延迟的患者。性腺发育不全占119例中的39例（32.8%），生理性延迟占119例中的27例（22.7%），先天性无阴道综合征占119例中的17例（14.3%），高催乳素血症占119例中的11例（9.2%）。生理性延迟、高催乳素血症或多囊卵巢综合征的女孩随后具有正常的生殖潜力。在青春期发育异常的治疗中，个体化治疗很重要。
