Gossec L, Dougados M
René Descartes University, Cochin Hospital, Paris, France.
Clin Exp Rheumatol. 2003 Sep-Oct;21(5 Suppl 31):S174-8.
The course of rheumatoid arthritis (RA) is determined early and the goals in early RA are to prevent radiologic joint degradation and to achieve optimal clinical and biological remission. Achieving these goals means that many RA patients may be candidates for combination disease-modifying therapy. We review data from randomized clinical trials regarding the impact of these treatment strategies as the initial therapy in early RA. It appears likely that the place of combination therapy will increase in the coming decades, even in very early RA patients, where the ultimate goal is persistent remission.
类风湿关节炎（RA）的病程在早期就已确定，早期RA的治疗目标是预防关节影像学破坏，并实现最佳的临床和生物学缓解。实现这些目标意味着许多RA患者可能适合联合使用改善病情的疗法。我们回顾了关于这些治疗策略作为早期RA初始治疗的影响的随机临床试验数据。在未来几十年里，联合治疗的应用可能会增加，即使是在最终目标是持续缓解的极早期RA患者中。
