Owecki Maciej, Horst-Sikorska Wanda, Sowiński Jerzy
Katedra i Klinika Endokrynologii, Przemiany Materii i Chorób Wewnetrznych Akademii Medycznej w Poznaniu.
Pol Merkur Lekarski. 2003 Nov;15(89):445-8.
Sulfonylureas are commonly used antidiabetic oral agents. They act through a receptor in the beta cell membrane, which is called the sulfonylurea receptor 1 (SUR1). SUR1 together with Kir 6.2 protein assembles into a potassium channel, playing a key role in the regulation of insulin secretion. The work discusses up to date views on the structure and function of sulfonylurea receptors and potassium channels as well as clinical implications of their disturbances.
磺脲类药物是常用的口服抗糖尿病药物。它们通过β细胞膜上的一种受体起作用，这种受体被称为磺脲类受体1（SUR1）。SUR1与Kir 6.2蛋白一起组装成一个钾通道，在胰岛素分泌调节中起关键作用。这项工作讨论了关于磺脲类受体和钾通道的结构与功能的最新观点以及它们功能紊乱的临床意义。
