Ha-ras对有丝分裂原诱导的Ca(2+)和K(+)通量的影响。
Effect of Ha-ras on mitogen-induced Ca(2+)- and K(+)-fluxes.
作者信息
Grunicke H, Maly K, Meyer M, Oberhuber H, Bichler I, Waldegger L S, Woell E, Lang F
机构信息
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.
出版信息
Adv Enzyme Regul. 1992;32:163-76. doi: 10.1016/0065-2571(92)90015-r.
PMID:1496916
Abstract
Transforming Ha-ras enhances the mitogen-induced activation of both the Ca(2+)-influx and the furosemide-sensitive Na+/K+/2Cl-cotransporter. Both systems represent essential early steps of mitogenic signal transduction in NIH 3T3 fibroblasts.
摘要
转化型Ha-ras增强了有丝分裂原诱导的Ca(2+)内流和呋塞米敏感的Na+/K+/2Cl共转运体的激活。这两个系统都是NIH 3T3成纤维细胞中有丝分裂信号转导的重要早期步骤。
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