Ragin Ann B, Storey Pippa, Cohen Bruce A, Epstein Leon G, Edelman Robert R
Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
AJNR Am J Neuroradiol. 2004 Feb;25(2):195-200.
Quantitative MR imaging strategies may have considerable potential for in vivo assessment of neuropathologic changes associated with HIV. This investigation evaluated the prognostic significance of whole brain histogram-derived diffusion tensor imaging indices with respect to severity of cognitive impairment and measures of clinical status in cases of HIV.
Quantitative indices derived with diffusion tensor imaging, including whole brain fractional anisotropy and the apparent diffusion coefficient, were compared for six patients with HIV and eight control volunteers. Relationships between whole brain indices and specific measures of dementia severity and clinical status were examined.
Whole brain fractional anisotropy was reduced in patients with HIV and was significantly associated with severity of dementia, as indicated by several widely used clinical and functional status measures. Summary fractional anisotropy measures were more prognostic of dementia status than were apparent diffusion coefficient measures.
Findings from this investigation support the use of diffusion tensor imaging for noninvasive MR imaging measurement of neuropathologic changes in studies of HIV-associated cognitive impairment.
定量磁共振成像策略在体内评估与HIV相关的神经病理变化方面可能具有巨大潜力。本研究评估了全脑直方图衍生的扩散张量成像指标对HIV患者认知障碍严重程度和临床状态测量的预后意义。
比较了6例HIV患者和8名对照志愿者的扩散张量成像定量指标,包括全脑分数各向异性和表观扩散系数。研究了全脑指标与痴呆严重程度和临床状态的特定测量之间的关系。
HIV患者的全脑分数各向异性降低,并且与痴呆严重程度显著相关,这由几种广泛使用的临床和功能状态测量指标所表明。总结分数各向异性测量对痴呆状态的预后比表观扩散系数测量更好。
本研究结果支持在HIV相关认知障碍研究中使用扩散张量成像进行神经病理变化的无创磁共振成像测量。