Moyano J R, Ventriglia T, Ginés J M, Muñoz F, Rabasco A M
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain.
Boll Chim Farm. 2003 Nov;142(9):390-5.
The interaction of glimepiride with b-cyclodextrin (b-CD) has been studied by several analytical techniques, including 1H NMR, infrared spectroscopy (FTIR), powder x-ray diffractometry (XRD), thermal analysis (DSC) and scanning electron microscopy (SEM). The existence of an inclusion complex was proved in solution by phase solubility techniques and 1H NMR, and in the solid state by DSC, FTIR and XRD, being isolated by sealed heating and freeze drying procedures.
已通过多种分析技术研究了格列美脲与β-环糊精（β-CD）的相互作用，这些技术包括1H核磁共振、红外光谱（傅里叶变换红外光谱）、粉末X射线衍射、热分析（差示扫描量热法）和扫描电子显微镜。通过相溶解度技术和1H核磁共振在溶液中证明了包合物的存在，通过差示扫描量热法、傅里叶变换红外光谱和X射线衍射在固态中证明了包合物的存在，并通过密封加热和冷冻干燥程序将其分离出来。
