El-Aswad Ahmed F, Abdelgaleil Samir A M, Nakatani Munehiro
Pesticide Chemistry Department, Faculty of Agriculture (Elshatby), Alexandria University, Alexandria, Egypt.
Pest Manag Sci. 2004 Feb;60(2):199-203. doi: 10.1002/ps.818.
Three rearranged phragmalin-type limonoids, khayanolide A, khayanolide B and 1-O-acetylkhayanolide B, and a mexicanolide-type limonoid, khayalactol, have been isolated from the stem bark of Khaya senegalensis (Desr) A Juss (Meliaceae). The antifeedant and growth-inhibitory activities of the isolated compounds were evaluated on Spodoptera littoralis (Boisduval). When added to an artificial diet, khayanolide A, khayanolide B and 1-O-acetylkhayanolide B showed antifeedant activity in a concentration-dependent manner. Khayalactol exhibited strong antifeedant activity without significant differences at all of the tested concentrations (7.5-100 mg kg(-1)). Khayanolide B was the most potent antifeedant with an ECso of 2.19 mg kg(-1). The results also revealed that the isolated compounds caused marked larval growth inhibition on S littoralis after 7 days of feeding on treated diet; this effect was concentration-dependent. Khayanolide B was the most active growth inhibitor among the isolated compounds, with an EC50 of 6.96 mg kg(-1).
从塞内加尔桃花心木（Khaya senegalensis (Desr) A Juss，楝科）的茎皮中分离出了三种重排的苦木素型柠檬苦素类化合物——卡亚诺内酯A、卡亚诺内酯B和1 - O - 乙酰卡亚诺内酯B，以及一种墨西哥苦素型柠檬苦素类化合物——卡亚内酯醇。对所分离化合物的拒食活性和生长抑制活性在埃及棉铃虫（Spodoptera littoralis (Boisduval)）上进行了评估。当添加到人工饲料中时，卡亚诺内酯A、卡亚诺内酯B和1 - O - 乙酰卡亚诺内酯B呈浓度依赖性地表现出拒食活性。卡亚内酯醇在所有测试浓度（7.5 - 100 mg kg(-1)）下均表现出较强的拒食活性，且无显著差异。卡亚诺内酯B是最有效的拒食剂，其半数有效浓度（ECso）为2.19 mg kg(-1)。结果还表明，在以经处理的饲料喂养7天后，所分离的化合物对埃及棉铃虫幼虫生长有显著抑制作用；这种作用呈浓度依赖性。在所分离的化合物中，卡亚诺内酯B是最具活性的生长抑制剂，其半数有效浓度（EC50）为6.96 mg kg(-1)。
