用于深度分辨检测组织中光热响应的差分相位光学相干探头。

Differential phase optical coherence probe for depth-resolved detection of photothermal response in tissue.

作者信息

Telenkov Sergey A, Dave Digant P, Sethuraman Shriram, Akkin Taner, Milner Thomas E

机构信息

Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA.

出版信息

Phys Med Biol. 2004 Jan 7;49(1):111-9. doi: 10.1088/0031-9155/49/1/008.

DOI:10.1088/0031-9155/49/1/008

PMID:14971776

Abstract

We describe a differential phase low-coherence interferometric probe for non-invasive, quantitative imaging of photothermal phenomena in biological materials. Our detection method utilizes principles of optical coherence tomography with differential phase measurement of interference fringe signals. A dual-channel optical low-coherence probe is used to analyse laser-induced thermoelastic and thermorefractive effects in tissue with micrometre axial resolution and nanometre sensitivity. We demonstrate an application of the technique using tissue phantoms and ex-vivo tissue specimens of rodent dorsal skin.

摘要

我们描述了一种用于对生物材料中的光热现象进行非侵入性定量成像的差分相位低相干干涉测量探头。我们的检测方法利用了光学相干断层扫描原理以及干涉条纹信号的差分相位测量。一个双通道光学低相干探头被用于分析组织中的激光诱导热弹性和热折射效应，具有微米级的轴向分辨率和纳米级的灵敏度。我们展示了该技术在组织模型和啮齿动物背部皮肤离体组织标本上的应用。