University of Washington, Department of Bioengineering, 3720 15th Avenue N. E., Seattle, Washington 98195, USA.
J Biomed Opt. 2011 Dec;16(12):126003. doi: 10.1117/1.3659211.
A model that describes the concentration of photothermal (light-to-heat converters) compounds as a function of depth in a turbid medium is developed. The system consists of a pump laser (808 nm modulated at 400 Hz), which heats a photothermal compound, and a phase sensitive spectral domain optical coherence tomography system, which detects the changes in the optical path length of the sample induced by the temperature increase. The model is theoretically derived and the coefficients are empirically determined using solid homogeneous gel phantoms. The model is validated by reconstructing the concentration of a photothermal compound in thick single and double layer solid phantoms.
建立了一个描述光热（光热转换器）化合物浓度随混浊介质深度变化的模型。该系统由一个泵浦激光（808nm，400Hz 调制）组成，用于加热光热化合物，以及一个相敏谱域光学相干层析成像系统，用于检测由温度升高引起的样品光程长度的变化。该模型是从理论上推导出来的，系数是通过使用固体均匀凝胶模型来经验确定的。该模型通过重建单层和双层固体模型中光热化合物的浓度来验证。
